Los Feliz encompasses several smaller but distinct areas, including the Los Feliz Hills and Los Feliz Estates (north of Los Feliz Boulevard), Laughlin Park, Los Feliz Village, Los Feliz Square, Los Feliz Knolls, and Franklin Hills.

According to the Mapping L.A. project of the Los Angeles Times, Los Feliz is part of Central Los Angeles. It is flanked on the north by Griffith Park, on the northeast by Atwater Village, on the southeast by Silver Lake, on the south by East Hollywood, and on the northwest by Hollywood and Hollywood Hills.